TECHNOLOGY LICENSING OPPORTUNITY: NanoFETview on SAM.gov

NanoFiber Engineered Therapeutics Platform (NanoFET) from Los Alamos National Laboratory offers pharmaceutical and biodefense organizations a modular, adaptable scaffold for building next-generation immunotherapies. By merging self-assembling peptide nanofibers with interchangeable nanobody and peptide components, the platform enables rapid development of targeted treatments that bridge disease agents directly to the patient's own immune cells. Infectious diseases and chronic conditions such as cancer continue to impose enormous public health and economic burdens worldwide. Conventional vaccines and biologics are typically designed against a single pathogen or target, leaving populations vulnerable when new or unknown threats emerge. For military personnel and first responders, the absence of broad-spectrum medical countermeasures means that exposure to an unidentified pathogen in the field can be met with little more than supportive care. In cancer immunotherapy, connecting tumor cells to the patient's own immune effector cells remains a formidable engineering challenge; current bispecific antibody formats are complex to manufacture, expensive and often limited in the number of targets they can engage simultaneously. Meanwhile, traditional antibody-based therapeutics are large molecules that can be difficult to produce at scale, may trigger unwanted immune reactions and lack the modularity needed for rapid adaptation to new disease targets. A platform capable of addressing multiple threats through a single reconfigurable architecture would represent a meaningful shift in how therapeutics are developed and deployed. Advantages: Modular architecture allows rapid swapping of nanobodies and peptides to address new disease targets without redesigning the core platform Dual-function capability bridges disease agents directly to immune cells on a single construct, enabling both targeted and broad-spectrum responses Adjuvant-free immune activation through self-assembling nanofibers that inherently stimulate robust, innate immune responses Small, stable targeting molecules (nanobodies) that are easier to produce and engineer than conventional full-size antibodies High-density multivalent display presents multiple antigens or functional components simultaneously, enhancing immune recognition Compatibility with external biologics enables partners to integrate their own AI-designed binders or proprietary targeting molecules onto the nanofiber scaffold Market Applications Oncology (bispecific T-cell engagers, tumor-targeted immunotherapies, combination immunotherapy platforms) Infectious Disease Therapeutics (pan-influenza treatments, broad-spectrum antiviral and antibacterial countermeasures, emerging pathogen response) Biodefense and Military Medicine (medical countermeasures for warfighters, rapid-response therapeutics for unknown biological threats, field-deployable immune enhancers) Vaccine Development (multiantigen vaccine platforms, adjuvant-free sub…